PEGylation of protein-imprinted nanocomposites sandwiching CdTe quantum dots with enhanced fluorescence sensing selectivity.

ABSTRACT: Fluorescent sensors combining the selective recognition of protein molecularly imprinted polymers (MIPs) and the fluorescent sensing of quantum dots (QDs) have been studied considerably, but their fluorescence sensing selectivity for the target proteins remains to be increased. Herein, we propose a strategy for increasing the sensing selectivity by post-imprinting PEGylation of surface protein-imprinted nanocomposites with embedded QDs. With bovine hemoglobin (BHb) as a model protein template, protein MIP nanolayers were anchored over the CdTe QD decorated SiO₂ nanoparticles by the sol-gel process using aminopropyltriethoxy silane and tetraethoxysilicane. PEG chains were then grafted onto the surface of the imprinted nanostructures via the nucleophilic reaction of the sur

SUBMITTER: Han X 

PROVIDER: S-EPMC9075826 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature