Dynamic Halbach array magnet integrated microfluidic system for the continuous-flow separation of rare tumor cells.

ABSTRACT: Circulating tumor cells (CTCs), the most representative rare cells in peripheral blood, have received great attention due to their clinical utility in liquid biopsy. The downstream analysis of intact CTCs isolated from peripheral blood provides important clinical information for personalized medicine. However, current CTC isolation and detection methods have been challenged by their extreme rarity and heterogeneity. In this study, we developed a novel microfluidic system with a continuously moving Halbach array magnet (dHAMI microfluidic system) for negative isolation CTCs from whole blood, which aimed to capture non-target white blood cells (WBCs) and elute target CTCs. The dynamic and continuous movement of the Halbach array magnet generated a continuous magnetic force acting on the magn

SUBMITTER: Xue M 

PROVIDER: S-EPMC9075830 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature