Non-natural 2H-azirine-2-carboxylic acids: an expedient synthesis and antimicrobial activity.

ABSTRACT: Non-natural 2H-azirine-2-carboxylic acids were obtained in high yields by FeCl₂-catalyzed isomerization of 5-chloroisoxazoles to azirine-2-carbonyl chlorides followed by their hydrolysis. The 3-aryl- and 3-heteroaryl-substituted acids are stable during prolonged storage, exhibit antibacterial activity against ESKAPE pathogens and show a low level of cytotoxicity.

SUBMITTER: Sakharov PA 

PROVIDER: S-EPMC9075858 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature