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The balancing role of distribution speed against varying efficacy levels of COVID-19 vaccines under variants.

ABSTRACT: During a pandemic, vaccination plays an important role in reducing the infection spread or adverse outcomes such as hospitalizations and deaths. However, a vaccine's overall public health impact depends not only on its initial efficacy, but also its efficacy against emerging variants and ease and speed of distribution. For example, mutations in SARS-CoV-2 raised concerns about diminishing vaccine effectiveness against COVID-19 caused by particular variants. Furthermore, due to supply-chain challenges, the accessibility and distribution of the vaccines have been hindered in many regions, especially in low-income countries, while the second or third wave of the COVID-19 pandemic has occurred due to the variants. Hence, we evaluated the interactions between the speed of distribution and efficacy against infection of multiple vaccines when variants emerge by utilizing a Susceptible-Infected-Recovered-Deceased model and assessing the level of infection attack rate. Our results show that speed is a key factor to a successful immunization strategy to control the pandemic even when the emerging variants may reduce the efficacy of a vaccine. Understanding the interactions between speed and efficacy and distributing vaccines that are available as quickly as possible are crucial to eradicate the pandemic before new variants spread.

SUBMITTER: Kim D

PROVIDER: S-EPMC9075929 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

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The balancing role of distribution speed against varying efficacy levels of COVID-19 vaccines under variants.

Kim Daniel D Keskinocak Pınar P Pekgün Pelin P Yildirim İnci İ

Scientific reports 20220506 1

During a pandemic, vaccination plays an important role in reducing the infection spread or adverse outcomes such as hospitalizations and deaths. However, a vaccine's overall public health impact depends not only on its initial efficacy, but also its efficacy against emerging variants and ease and speed of distribution. For example, mutations in SARS-CoV-2 raised concerns about diminishing vaccine effectiveness against COVID-19 caused by particular variants. Furthermore, due to supply-chain chall ...[more]

PMID: 35523832

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Dataset Information

The balancing role of distribution speed against varying efficacy levels of COVID-19 vaccines under variants.

Publications

The balancing role of distribution speed against varying efficacy levels of COVID-19 vaccines under variants.

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