UPLC-QTOF-MS-guided isolation of anti-COPD ginsenosides from wild ginseng.

ABSTRACT: Four previously undescribed ginsenosides, along with five known analogues were isolated from wild ginseng by a UPLC-QTOF-MS-guided fractionation procedure. Their structures were elucidated on the basis of spectroscopic and spectrometric data (1D and 2D NMR, HR-ESI-MS). The isolated compounds could significantly inhibit the cigarette smoke extract (CSE)-induced inflammatory reaction in A549 cells. The HDAC2 pathway might be involved in the protective effect against the CSE-mediated inflammatory response in A549 cells.

SUBMITTER: Zhu H 

PROVIDER: S-EPMC9075943 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature