Oxytocin neurons mediate the effect of social isolation via the VTA circuits.

ABSTRACT: Social interaction during adolescence strongly influences brain function and behavior, and the recent pandemic has emphasized the devastating effect of social distancing on mental health. While accumulating evidence has shown the importance of the reward system in encoding specific aspects of social interaction, the consequences of social isolation on the reward system and the development of social skills later in adulthood are still largely unknown. Here, we found that 1 week of social isolation during adolescence in male mice increased social interaction at the expense of social habituation and social novelty preference. Behavioral changes were accompanied by the acute hyperexcitability of putative dopamine (pDA) neurons in the ventral tegmental area and long-lasting expression of GluA2-

SUBMITTER: Musardo S 

PROVIDER: S-EPMC9075949 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature