Parent-of-origin effects propagate through networks to shape metabolic traits.

ABSTRACT: Parent-of-origin effects are unexpectedly common in complex traits, including metabolic and neurological traits. Parent-of-origin effects can be modified by the environment, but the architecture of these gene-by-environmental effects on phenotypes remains to be unraveled. Previously, quantitative trait loci (QTL) showing context-specific parent-of-origin effects on metabolic traits were mapped in the F₁₆ generation of an advanced intercross between LG/J and SM/J inbred mice. However, these QTL were not enriched for known imprinted genes, suggesting another mechanism is needed to explain these parent-of-origin effects phenomena. We propose that non-imprinted genes can generate complex parent-of-origin effects on metabolic traits through interactions with imprinted genes. Here, we

SUBMITTER: Macias-Velasco JF 

PROVIDER: S-EPMC9075957 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature