Anticancer and antimicrobial properties of novel η⁶-p-cymene ruthenium(ii) complexes containing a N,S-type ligand, their structural and theoretical characterization.

ABSTRACT: Ruthenium(ii) complexes are lately of great scientific interest due to their chemotherapeutic potential as anticancer and antimicrobial agents. Here we present the synthesis of new pyrazole carbothioamide derivatives and their four arene-ruthenium complexes. The title compounds were characterized with the application of IR, NMR, mass spectrometry, elemental analysis and X-ray diffraction. Additionally, for new complexes DFT calculations were done. Their antimicrobial activity (MIC, MBC/MFC) was examined in vitro against Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Pseudomonas aeruginosa, Proteus vulgaris and Candida albicans. Their cytotoxic effects, using the MTT assay, against three cancer cell lines: HL-60, NA

SUBMITTER: Namiecinska E 

PROVIDER: S-EPMC9075995 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature