Excited-state locked amino analogues of the green fluorescent protein chromophore with a giant Stokes shift.

ABSTRACT: We design a novel class of excited-state locked GFP chromophores by introducing an amine group at the double exo-bond and a difluoroboryl bridge. We show that these chromophores intrinsically exhibit a very large Stokes shift of 1 eV. Further tuning through chemical modifications of their aryl substituents makes them environmentally sensitive.

SUBMITTER: Zaitseva SO 

PROVIDER: S-EPMC9076007 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature