An NIR-triggered drug release and highly efficient photodynamic therapy from PCL/PNIPAm/porphyrin modified graphene oxide nanoparticles with the Janus morphology.

ABSTRACT: This project aimed to investigate the synthesis and characteristics of stimuli-responsive nanoparticles with different morphologies. In the first step, graphene oxide was synthesized based on the improved Hummers' method. Then, thermo-responsive poly(N-isopropylacrylamide-co-N-(hydroxymethyl)acrylamide), an amphiphilic copolymer, and poly(caprolactone) (PCL), a hydrophobic polymer, were used to prepare Janus and mixed graphene oxide-based nanoparticles. Fluorescence microscopy was utilized to confirm the Janus structure by labeling the mixed and Janus NPs with fluorescent hydrophobic and hydrophilic dyes via a solvent-evaporation method. Then, terminally modified carboxyl porphyrin (TPPC3-COOH), used as the second generation photosensitizer, was grafted to the copolyme

SUBMITTER: Khoee S 

PROVIDER: S-EPMC9076064 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature