Electrophilically activated nitroalkanes in reaction with aliphatic diamines en route to imidazolines.

ABSTRACT: A novel synthetic methodology for the assembly of imidazolines via an unusual reaction between nitroalkanes and aliphatic 1,2-diamines in the presence of phosphorous acid is described. In contrast to the related highly efficient preparation of benzimidazoles from aromatic amines, this process represents a major synthetic challenge and for a long time was elusive. Analysis of the method limitations is provided.

SUBMITTER: Aksenov AV 

PROVIDER: S-EPMC9076073 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature