Highly water-dispersible calcium lignosulfonate-capped MnO nanoparticles as a T ₁ MRI contrast agent with exceptional colloidal stability, low toxicity and remarkable relaxivity.

ABSTRACT: A simple and efficient method to synthesize highly water-dispersible calcium lignosulfonate-coated manganese oxide nanoparticles as a potential candidate for the current magnetic resonance imaging (MRI) T ₁ contrast agents was reported. Hydrophobic MnO nanoparticles with dimensions of about 10 nm were prepared by thermal decomposition of manganese(ii)acetylacetonate in the presence of oleic acid as a surfactant. The characteristics of the synthesized nanoparticles, cytotoxicity assay and in vitro MRI properties were investigated in detail. Results showed that calcium lignosulfonate has a great influence on the colloidal stability and biocompatibility of MnO nanoparticles in water. Furthermore, this coating agent ensures abundant exposure of external Mn ion with pro

SUBMITTER: Arian M 

PROVIDER: S-EPMC9076238 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature