Mild polyaddition and polyalkylation based on the carbon-carbon bond formation reaction of active methylene.

ABSTRACT: The Michael addition and alkylation reaction of active methylene compounds (AMCs) with two active hydrogens had been investigated extensively in organic chemistry, while the polymerization of AMCs had few studies. Herein, we reported active methylene-based polyaddition and polyalkylation catalyzed via an organic superbase under ambient conditions. A model polymerization was first conducted between ethylene glycol diacrylate (EGDA) and methyl cyanoacetate (MCA). The molecular weight (M _w) of the model polymer was up to 50 500 g mol^-1 with a high yield (99%). Eight AMCs were selected and a high-throughput parallel synthesizing instrument (HTPSI) was used to synthesize semi-library polymers of AMCs and EGDA via a Michael type polyaddition. The obtain

SUBMITTER: Jiao C 

PROVIDER: S-EPMC9076256 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature