Thermoresponsive P(HEMA-co-OEGMA) copolymers: synthesis, characteristics and solution behavior.

ABSTRACT: Random, thermoresponsive copolymers of 2-hydroxyethyl methacrylate (HEMA) and oligo(ethylene glycol) methyl ether methacrylate M _n = 300 (OEGMA) were synthesized via atom transfer radical polymerization (ATRP) in a DMSO/H₂O solvent mixture. Reactivity ratios were determined by the extended Kelen-Tudos method and found to be close to 1. Studies confirmed the randomness of the obtained copolymers. The thermoresponsiveness in water and in phosphate buffer (PBS) solutions and the influence of copolymer composition and solution concentration on the cloud point temperature (T _cp) were investigated. Phase transitions in water solutions were reversible and narrow. The response of P(HEMA-co-OEGMA) to temperature could be adjusted in the r

SUBMITTER: Kasprow M 

PROVIDER: S-EPMC9076357 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature