PH-responsive polymeric vesicles from branched copolymers.

ABSTRACT: A new type of branched copolymer, poly(l-lactide)₂-b-poly(l-glutamic acid) (PLLA₂-PLGA), based on polypeptide PLGA is synthesized by the ring-opening polymerization (ROP) of N-carboxyanhydride of γ-benzyl-l-glutamate (BLG-NCA) with amino-terminated PLLA₂-NH₂ and subsequent deprotection. The branched copolymer is characterized by ¹H NMR, FTIR and GPC measurements. The self-assembly of the copolymers in aqueous media has been systematically discussed. A pyrene probe has been used to demonstrate the aggregated formation of PLLA₂-PLGA in solution by measuring the critical micelle concentration (cmc). The morphology and size of the micelles have further been studied by transmission electron microscopy (TEM), dynamic

SUBMITTER: Zhou J 

PROVIDER: S-EPMC9076388 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature