Sodium-containing acetaminophen and cardiovascular outcomes in individuals with and without hypertension.

ABSTRACT:

Aims

Previous studies have found high sodium intake to be associated with increased risks of cardiovascular disease (CVD) and all-cause mortality among individuals with hypertension; findings on the effect of intake among individuals without hypertension have been equivocal. We aimed to compare the risks of incident CVD and all-cause mortality among initiators of sodium-containing acetaminophen with the risk of initiators of non-sodium-containing formulations of the same drug according to the history of hypertension.

Methods and results

Using The Health Improvement Network, we conducted two cohort studies among individuals with and without hypertension. We examined the relation of sodium-containing acetaminophen to the risk of each outcome during 1-year follow-up using margi

SUBMITTER: Zeng C 

PROVIDER: S-EPMC9076395 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature