A polygenic risk score improves risk stratification of coronary artery disease: a large-scale prospective Chinese cohort study.

ABSTRACT:

Aims

To construct a polygenic risk score (PRS) for coronary artery disease (CAD) and comprehensively evaluate its potential in clinical utility for primary prevention in Chinese populations.

Methods and results

Using meta-analytic approach and large genome-wide association results for CAD and CAD-related traits in East Asians, a PRS comprising 540 genetic variants was developed in a training set of 2800 patients with CAD and 2055 controls, and was further assessed for risk stratification for CAD integrating with the guideline-recommended clinical risk score in large prospective cohorts comprising 41 271 individuals. During a mean follow-up of 13.0 years, 1303 incident CAD cases were identified. Individuals with high PRS (the highest 20%) had about three-fold higher risk of C

SUBMITTER: Lu X 

PROVIDER: S-EPMC9076396 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature