Stochastic Epigenetic Mutations Influence Parkinson's Disease Risk, Progression, and Mortality.

ABSTRACT:

Background

Stochastic epigenetic mutations (SEM) reflect a deviation from normal site-specific methylation patterns. Epigenetic mutation load (EML) captures the accumulation of SEMs across an individual's genome and may reflect dysfunction of the epigenetic maintenance system in response to epigenetic challenges.

Objective

We investigate whether EML is associated with PD risk and time to events (i.e., death and motor symptom decline).

Methods

We employed logistic regression and Cox proportional hazards regression to assess the association between EML and several outcomes. Our analyses are based on 568 PD patients and 238 controls from the Parkinson's disease, Environment and Genes (PEG) study, for whom blood-based methylation data was available.

Results

We foun

SUBMITTER: Chen GK 

PROVIDER: S-EPMC9076404 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature