Aortic stiffness is lower when PVAT is included: a novel ex vivo mechanics study.

ABSTRACT: Perivascular adipose tissue (PVAT) is increasingly recognized as an essential layer of the functional vasculature, being responsible for producing vasoactive substances and assisting arterial stress relaxation. Here, we test the hypothesis that PVAT reduces aortic stiffness. Our model was the thoracic aorta of the male Sprague-Dawley rat. Uniaxial mechanical tests for three groups of tissue were performed: aorta with PVAT attached (+PVAT) or removed (-PVAT), and isolated PVAT (PVAT only). The output of the mechanical test is reported in the form of a Cauchy stress-stretch curve. This work presents a novel, physiologically relevant approach to measure mechanical stiffness ex vivo in isolated PVAT. Low-stress stiffness (E₀), high-stress stiffness (E₁), and

SUBMITTER: Tuttle T 

PROVIDER: S-EPMC9076424 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature