Carbon dot mediated G quadruplex nano-network formation for enhanced DNAzyme activity and easy catalyst reclamation.

ABSTRACT: The significant application potential of the DNAzyme activity of G-quadruplex (G4)-hemin complexes has prompted considerable research efforts to amplify their peroxidase mimicking activity to match that of their enzymatic counterparts. However, concurrent improvements in the catalytic cycle and catalyst recovery remain elusive. Herein, we report the creation of a network array of G-quadruplex (G4)-hemin complexes crosslinked by carbon quantum dots (CDs) that not only significantly improves the G-quadruplex-hemin DNAzyme activity, stability, and catalytic cycle, but also points towards easy catalyst regeneration via a semi-heterogeneous catalysis approach. 5'-phosphate terminated G-rich single-stranded DNA molecules proficient in generating intermolecular and intramolecular G-quadrup

SUBMITTER: Kumari S 

PROVIDER: S-EPMC9076458 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature