Hybrid analytical-numerical approach for investigation of differential effects in normal and cancer cells under electroporation.

ABSTRACT: Electroporation has offered important biomedical applications in electrochemotherapy, tissue ablation and gene editing recently. Time and computation efficient analytical and numerical models should be developed to understand the differential effects of electroporation on normal and cancer cells. In this work, we present a hybrid analytical-numerical approach to investigate the behavior of normal and cancer cells under electroporation. We have compared the human breast cancer cell (MCF-7) and non-tumorigenic human breast cell (MCF-10A) under electroporation in terms of change in transmembrane voltage and pore formation on cell surface. The effects of electric pulse time, amplitude and membrane conductivity variation are analyzed in a systematic manner. To accelerate the calculation of tran

SUBMITTER: Aslam MA 

PROVIDER: S-EPMC9076493 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature