Facile one-pot synthesis of novel N-benzimidazolyl-α-arylnitrones catalyzed by salts of transition metals.

ABSTRACT: A novel series of N-benzimidazol-2-yl-α-aryl nitrones 3a-j is synthesized via simple one-pot condensation/oxidation of 2-aminobenzimidazole, an aromatic aldehyde and m-chloro perbenzoic acid (m-CPBA) as an effective oxidant using Mn(NO₃)₂·6H₂O as an efficient catalyst at room temperature. All synthesized N-benzimidazolyl nitrones were identified using FTIR, NMR and mass spectroscopy. Also, stability energy theory calculations were performed and ¹H NMR computational spectra were generated for the isomeric structures of 3a; the results show that the stability order is oxaziridine (4) followed by the nitrones 3a _E and 3a _Z . Also, comparing the computational spectroscopy results

SUBMITTER: Kalhor M 

PROVIDER: S-EPMC9076553 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature