The interaction between endogenous GABA, functional connectivity, and behavioral flexibility is critically altered with advanced age.

ABSTRACT: The flexible adjustment of ongoing behavior challenges the nervous system's dynamic control mechanisms and has shown to be specifically susceptible to age-related decline. Previous work links endogenous gamma-aminobutyric acid (GABA) with behavioral efficiency across perceptual and cognitive domains, with potentially the strongest impact on those behaviors that require a high level of dynamic control. Our analysis integrated behavior and modulation of interhemispheric phase-based connectivity during dynamic motor-state transitions with endogenous GABA concentration in adult human volunteers. We provide converging evidence for age-related differences in the preferred state of endogenous GABA concentration for more flexible behavior. We suggest that the increased interhemispheric connectivit

SUBMITTER: Heise KF 

PROVIDER: S-EPMC9076638 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature