Young-onset diabetes in Asian Indians is associated with lower measured and genetically determined beta cell function.

ABSTRACT:

Aims/hypothesis

South Asians in general, and Asian Indians in particular, have higher risk of type 2 diabetes compared with white Europeans, and a younger age of onset. The reasons for the younger age of onset in relation to obesity, beta cell function and insulin sensitivity are under-explored.

Methods

Two cohorts of Asian Indians, the ICMR-INDIAB cohort (Indian Council of Medical Research-India Diabetes Study) and the DMDSC cohort (Dr Mohan's Diabetes Specialties Centre), and one of white Europeans, the ESDC (East Scotland Diabetes Cohort), were used. Using a cross-sectional design, we examined the comparative prevalence of healthy, overweight and obese participants with young-onset diabetes, classified according to their BMI. We explored the role of clinically measured be

SUBMITTER: Siddiqui MK 

PROVIDER: S-EPMC9076730 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature