Network pharmacology of iridoid glycosides from Eucommia ulmoides Oliver against osteoporosis.

ABSTRACT: Eucommia ulmoides Oliver is one of the commonly used traditional Chinese medicines for the treatment of osteoporosis, and iridoid glycosides are considered to be its active ingredients against osteoporosis. This study aims to clarify the chemical components and molecular mechanism of iridoid glycosides of Eucommia ulmoides Oliver in the treatment of osteoporosis by integrating network pharmacology and molecular simulations. The active iridoid glycosides and their potential targets were retrieved from text mining as well as Swiss Target Prediction, TargetNet database, and STITCH databases. At the same time, DisGeNET, GeneCards, and Therapeutic Target Database were used to search for the targets associated with osteoporosis. A protein-protein interaction network was built to analyze the inte

SUBMITTER: Wang T 

PROVIDER: S-EPMC9076851 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature