A serotonergic biobehavioral signature differentiates cocaine use disorder participants administered mirtazapine.

ABSTRACT: Cocaine use disorder (CUD) patients display heterogenous symptoms and unforeseeable responses to available treatment approaches, highlighting the need to identify objective, accessible biobehavioral signatures to predict clinical trial success in this population. In the present experiments, we employed a task-based behavioral and pharmacogenetic-fMRI approach to address this gap. Craving, an intense desire to take cocaine, can be evoked by exposure to cocaine-associated stimuli which can trigger relapse during attempted recovery. Attentional bias towards cocaine-associated words is linked to enhanced effective connectivity (EC) from the anterior cingulate cortex (ACC) to hippocampus in CUD participants, an observation which was replicated in a new cohort of participants in the present stud

SUBMITTER: Ma L 

PROVIDER: S-EPMC9076859 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature