Butyrate administration is not sufficient to improve immune reconstitution in antiretroviral-treated SIV-infected macaques.

ABSTRACT: Defective gastrointestinal barrier function and, in turn, microbial translocation have been identified as significant contributors to persistent inflammation in antiretroviral (ARV)-treated people living with HIV. Metabolic supplementation of short-chain fatty acids (SCFAs), generally produced by the commensal microbiome, may improve these outcomes. Butyrate is a SCFA that is essential for the development and maintenance of intestinal immunity and has a known role in supporting epithelial integrity. Herein we assessed whether supplementation with the dietary supplement sodium butyrate would improve immune reconstitution and reduce inflammation in ARV-treated, simian immunodeficiency virus (SIV)-infected rhesus macaques. We demonstrate that butyrate supplementation does not significantly im

SUBMITTER: Ortiz AM 

PROVIDER: S-EPMC9076870 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature