Fluorescence imaging of hepatocellular carcinoma with a specific probe of COX-2.

ABSTRACT: Hepatocellular carcinoma (HCC) is the major subtype of primary liver cancer. Although the standard treatment method based on surgery has generally extended life, it still causes the second and sixth most prevalent cancer-related death in men and women, respectively. The recurrence of cancer caused by unclear resection margins and any remaining undiscovered metastatic nodules should take a large proportion of responsibility for the poor prognosis after resective surgery. Therefore, a practical and effective method that can be used during hepatectomy to specifically identify HCC is a potentially significant area deserving attention. Tests involving fluorescence have been used in many biological systems. In this study, we use a probe that can combine with cyclooxygenase-2 (COX-2) and subseque

SUBMITTER: Wang H 

PROVIDER: S-EPMC9076980 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature