A three-dimensional hydroxyapatite/polyacrylonitrile composite scaffold designed for bone tissue engineering.

ABSTRACT: In recent years, various composite scaffolds based on hydroxyapatite have been developed for bone tissue engineering. However, the poor cell survival micro-environment is still the major problem limiting their practical applications in bone repairing and regeneration. In this study, we fabricated a class of fluffy and porous three-dimensional composite fibrous scaffolds consisting of hydroxyapatite and polyacrylonitrile by employing an improved electrospinning technique combined with a bio-mineralization process. The fluffy structure of the hydroxyapatite/polyacrylonitrile composite scaffold ensured the cells would enter the interior of the scaffold and achieve a three-dimensional cell culture. Bone marrow mesenchymal stem cells were seeded into the scaffolds and cultured for 21 days in

SUBMITTER: Wu S 

PROVIDER: S-EPMC9077050 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature