Synthesis and kinetics of disassembly for silyl-containing ethoxycarbonyls using fluoride ions.

ABSTRACT: In this study, a series of silyl-containing ethoxycarbonates and ethoxycarbamates on electron poor anilines and phenols were synthesized and their kinetics of disassembly determined in real-time upon exposure to fluoride ion sources at room temperature. The results provide a greater understanding of stability and kinetics for silyl-containing protecting groups that eliminate volatile molecules upon removal, which will allow for simplification of orthogonal protection in complex organic molecules.

SUBMITTER: Camerino E 

PROVIDER: S-EPMC9077272 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature