"Turn on" room-temperature phosphorescent biosensors for detection of hyaluronic acid based on manganese-doped ZnS quantum dots.

ABSTRACT: Biosensors based on excellent optical properties of quantum dots (QDs) nanohybrids are efficient for biological detection. In this work, a room-temperature phosphorescent (RTP) PDAD-Mn-ZnS QDs biosensor was constructed with poly(diallyldimethylammonium chloride) (PDAD) as the modifier of MPA-capped Mn-ZnS QDs, and used to detect hyaluronic acid (HA). The newly-added HA induced severe electrostatic interaction with PDAD-Mn-ZnS QDs, leading to the aggregation between PDAD-Mn-ZnS QDs and HA and thereby enhancing RTP. The enhancement of RTP was proportional to the HA concentrations within certain ranges. On this basis, a high-performance HA sensor was built and this sensor had a detection limit of 0.03 μg mL^-1 and a detection range of 0.08-2.8 μg mL^-1. This proposed RTP s

SUBMITTER: Li D 

PROVIDER: S-EPMC9077376 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature