Ontology highlight
ABSTRACT:
SUBMITTER: Garcia S
PROVIDER: S-EPMC9077416 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Garcia Sofia S Saldana-Caboverde Amy A Anwar Mir M Raval Ami Pravinkant AP Nissanka Nadee N Pinto Milena M Moraes Carlos Torres CT Diaz Francisca F
Human molecular genetics 20220301 5
We analyzed early brain metabolic adaptations in response to mitochondrial dysfunction in a mouse model of mitochondrial encephalopathy with complex IV deficiency [neuron-specific COX10 knockout (KO)]. In this mouse model, the onset of the mitochondrial defect did not coincide with immediate cell death, suggesting early adaptive metabolic responses to compensate for the energetic deficit. Metabolomic analysis in the KO mice revealed increased levels of glycolytic and pentose phosphate pathway in ...[more]