Heart rate-corrected QT interval: A novel diagnostic biomarker for diabetic peripheral neuropathy.

ABSTRACT:

Aims/introduction

To explore the relationship between heart rate-corrected QT (QTc) interval and diabetic peripheral neuropathy (DPN), and whether QTc interval has diagnostic utility for DPN beyond nerve conduction velocity.

Materials and methods

A total of 965 patients with diabetes, including 473 patients with DPN and 492 patients without DPN, underwent standard 12-lead electrocardiography and detailed assessments of peripheral neuropathy.

Results

Patients with DPN had longer QTc intervals than those without. Among participants, from the first to fourth quartile of QTc interval, the proportion of patients with DPN appreciably increased and the nerve conduction velocity obviously decreased (P for trend <0.001). The univariate and multivariate analyses showed that pro

SUBMITTER: Jiang AJ 

PROVIDER: S-EPMC9077736 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature