Albumin-assisted exfoliated ultrathin rhenium disulfide nanosheets as a tumor targeting and dual-stimuli-responsive drug delivery system for a combination chemo-photothermal treatment.

ABSTRACT: Herein, we prepared an ultrathin rhenium disulfide nanosheet (utReS₂) through the bovine serum albumin (BSA)-assisted ultrasonic exfoliation method, which showed great biocompatibility and high near-infrared (NIR) absorbance. The large surface specific area and the presence of BSA facilitate a high loading ratio and modification of multifunctional molecules. The low solubility anti-cancer drug resveratrol (RSV) was loaded onto the utReS₂ surface to form a biocompatible nanocomposite (utReS₂@RSV). A targeting molecule, folic acid (FA), was then conjugated to the BSA molecule of utReS₂@RSV, resulting in utReS₂@RSV-FA. The utReS₂@RSV-FA exhibited a photothermal effect under an 808 nm laser irradiation. At pH = 6.5, about 16.5%

SUBMITTER: Huang Q 

PROVIDER: S-EPMC9077812 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature