Vapor deposition of polyionic nanocoatings for reduction of microglia adhesion.

ABSTRACT: Polyionics have great potential in improving the performance of neural probes by regulating microglial response. With the shrinkage of microelectrode size and increase in device complexity, challenges arise during liquid-based synthesis of polyionic compounds on neural probes. Nanocoatings of polyionics, with highly crosslinked bulk structure and abundant ionic functional groups on the surface, were synthesized using a process combining chemical vapor deposition and free radical polymerization. Both conformal surface engineering of neural microelectrodes and facile tailoring of surface ionic composition was achieved using this single-step vapor-based method. Adhesion of microglia was reduced on all the polyionic modified surfaces after a seven-day in vitro test, and polyionics with

SUBMITTER: Zhi B 

PROVIDER: S-EPMC9077851 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature