Association of FBN1 polymorphism with susceptibility of adolescent idiopathic scoliosis: a case-control study.

ABSTRACT:

Background

Fibrillin-1 (FBN1) is an extracellular matrix glycoprotein essential to the structural component of microfibrils and FBN1 gene polymorphisms can be associated with adolescent idiopathic scoliosis (AIS) susceptibility. This study aimed to evaluate the potential role of the FBN1 rs12916536 polymorphism in AIS development or severity and the variation in Cobb angle in relation to patient's characteristics.

Methods

DNA from 563 subjects (185 AIS patients and 378 controls) were genotyped using a validated TaqMan allelic discrimination assay. A multivariate logistic regression model evaluated the association between polymorphism and AIS, using the adjusted odds ratios (OR) with their respective 95% confidence intervals (95% CI). A linear regression analysis evaluated th

SUBMITTER: de Azevedo GBL 

PROVIDER: S-EPMC9077855 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature