Evolution and spread of a highly drug resistant strain of Mycobacterium tuberculosis in Papua New Guinea.

ABSTRACT:

Background

Molecular mechanisms determining the transmission and prevalence of drug resistant tuberculosis (DR-TB) in Papua New Guinea (PNG) are poorly understood. We used genomic and drug susceptibility data to explore the evolutionary history, temporal acquisition of resistance and transmission dynamics of DR-TB across PNG.

Methods

We performed whole genome sequencing on isolates from Central Public Health Laboratory, PNG, collected 2017-2019. Data analysis was done on a composite dataset that also included 100 genomes previously sequenced from Daru, PNG (2012-2015).

Results

Sampled isolates represented 14 of the 22 PNG provinces, the majority (66/94; 70%) came from the National Capital District (NCD). In the composite dataset, 91% of strains were Beijing 2.2.1.1, i

SUBMITTER: Bainomugisa A 

PROVIDER: S-EPMC9077924 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature