Early development of the cochlea of the common marmoset, a non-human primate model.

ABSTRACT:

Background

Fine-tuned cochlear development is essential for hearing. Owing to the difficulty in using early human fetal samples, most of our knowledge regarding cochlear development has been obtained from rodents. However, several inter-species differences in cochlear development between rodents and humans have been reported. To bridge these differences, we investigated early otic development of a non-human primate model animal, the common marmoset (Callithrix jacchus).

Methods

We examined 20 genes involved in early cochlear development and described the critical developmental steps for morphogenesis, which have been reported to vary between rodents and marmosets.

Results

The results revealed that several critical genes involved in prosensory epithelium specifications

SUBMITTER: Hosoya M 

PROVIDER: S-EPMC9077934 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature