Comparative 3D genome architecture in vertebrates.

ABSTRACT:

Background

The three-dimensional (3D) architecture of the genome has a highly ordered and hierarchical nature, which influences the regulation of essential nuclear processes at the basis of gene expression, such as gene transcription. While the hierarchical organization of heterochromatin and euchromatin can underlie differences in gene expression that determine evolutionary differences among species, the way 3D genome architecture is affected by evolutionary forces within major lineages remains unclear. Here, we report a comprehensive comparison of 3D genomes, using high resolution Hi-C data in fibroblast cells of fish, chickens, and 10 mammalian species.

Results

This analysis shows a correlation between genome size and chromosome length that affects chromosome territory (C

SUBMITTER: Li D 

PROVIDER: S-EPMC9077971 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature