Burden of rare coding variants reveals genetic heterogeneity between obese and non-obese asthma patients in the African American population.

ABSTRACT:

Background

Asthma is a complex condition largely attributed to the interactions among genes and environments as a heterogeneous phenotype. Obesity is significantly associated with asthma development, and genetic studies on obese vs. non-obese asthma are warranted.

Methods

To investigate asthma in the minority African American (AA) population with or without obesity, we performed a whole genome sequencing (WGS) study on blood-derived DNA of 4289 AA individuals, included 2226 asthma patients (1364 with obesity and 862 without obesity) and 2006 controls without asthma. The burden analysis of functional rare coding variants was performed by comparing asthma vs. controls and by stratified analysis of obese vs. non-obese asthma, respectively.

Results

Among the top 66 genes

SUBMITTER: Liu Y 

PROVIDER: S-EPMC9078008 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature