Association between high immune activity and worse prognosis in uveal melanoma and low-grade glioma in TCGA transcriptomic data.

ABSTRACT:

Background

Immune status in the tumor microenvironment is an important determinant of cancer progression and patient prognosis. Although a higher immune activity is often associated with a better prognosis, this trend is not absolute and differs across cancer types. We aimed to give insights into why some cancers do not show better survival despite higher immunity by assessing the relationship between different biological factors, including cytotoxicity, and patient prognosis in various cancer types using RNA-seq data collected by The Cancer Genome Atlas.

Results

Results showed that a higher immune activity was associated with worse overall survival in patients with uveal melanoma and low-grade glioma, which are cancers of immune-privileged sites. In these cancers, epithelia

SUBMITTER: Matsuo H 

PROVIDER: S-EPMC9078026 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature