Gadolinium-conjugated star-block copolymer polylysine-modified polyethylenimine as high-performance T ₁ MR imaging blood pool contrast agents.

ABSTRACT: Core-shell copolymers have received widespread attention because of their unique properties, such as suitable for surface modification and increasing the functionality. Thus, they have been increasingly used in many fields including biomedical, pharmaceutical, electronics and optics. Here, a new core-shell copolymer system was developed to synthesize potential blood pool contrast agent (CA) for magnetic resonance imaging (MRI). The novel CA with high T ₁ relaxivity was synthesized by conjugating gadolinium (Gd) chelators onto star-block copolymer polyethylenimine-grafted poly(l-lysine) (PEI-PLL) nanoparticles (NPs). The T ₁ relaxivity of PEI-PLL-DTPA-Gd NPs measured on a 7.0 T small animal MRI scanner was 8.289 mM^-1 s^-1, higher than

SUBMITTER: Huang Z 

PROVIDER: S-EPMC9078030 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature