Metabonomic strategy for the detection of metabolic effects of probiotics combined with prebiotic supplementation in weaned rats.

ABSTRACT: The purpose of this study is to investigate the effects of probiotics combined with prebiotics (PP) supplementation on weaned rat metabolism. A metabonomic strategy employing ¹H-NMR spectroscopy and multivariate data analysis was used to examine weaned rat biological responses to PP supplementation. Male Sprague-Dawley rats (post-natal day 21, PD 21) received probiotics (Lactobacillus acidophilus NCFM (L-NCFM) and Bifidobacterium lactis Bi-07 (B-LBi07), 1 : 1, 1.0 × 10¹¹ cfu kg^-1) and prebiotics (Lycium barbarum polysaccharides (LBP), Poria cocos polysaccharides (PCPs) and Lentinan, 1 : 1 : 1, 24 g kg^-1) via intragastric administration for 28 consecutive days. Urine and feces were collected

SUBMITTER: Wang M 

PROVIDER: S-EPMC9078034 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature