Age Differences in the Neural Correlates of Anxiety Disorders: An fMRI Study of Response to Learned Threat.

ABSTRACT:

Objective

Although both pediatric and adult patients with anxiety disorders exhibit similar neural responding to threats, age-related differences have been found in some functional MRI (fMRI) studies. To reconcile disparate findings, the authors compared brain function in youths and adults with and without anxiety disorders while rating fear and memory of ambiguous threats.

Methods

Two hundred medication-free individuals ages 8-50 were assessed, including 93 participants with an anxiety disorder. Participants underwent discriminative threat conditioning and extinction in the clinic. Approximately 3 weeks later, they completed an fMRI paradigm involving extinction recall, in which they rated their levels of fear evoked by, and their explicit memory for, morph stimuli with var

SUBMITTER: Gold AL 

PROVIDER: S-EPMC9078083 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature