Transcriptomic signals of mitochondrial dysfunction and OXPHOS dynamics in fast-growth chicken.

ABSTRACT:

Introduction

Birds are equipped with unique evolutionary adaptations to counter oxidative stress. Studies suggest that lifespan is inversely correlated with oxidative damage in birds. Mitochondrial function and performance are critical for cellular homeostasis, but the age-related patterns of mitochondrial gene expression and oxidative phosphorylation (OXPHOS) in birds are not fully understood. The domestic chicken is an excellent model to understand aging in birds; modern chickens are selected for rapid growth and high fecundity and oxidative stress is a recurring feature in chicken. Comparing fast- and slow-growing chicken phenotypes provides us an opportunity to disentangle the nexus of oxidative homeostasis, growth rate, and age in birds.

Methods and results

We compared

SUBMITTER: Hubert S 

PROVIDER: S-EPMC9078135 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature