Michellamines A₆ and A₇, and further mono- and dimeric naphthylisoquinoline alkaloids from a Congolese Ancistrocladus liana and their antiausterity activities against pancreatic cancer cells.

ABSTRACT: Michellamines A₆ (1) and A₇ (2) are the first dimers of 5,8'-coupled naphthylisoquinoline alkaloids with cis-configured stereocenters in both tetrahydroisoquinoline subunits. They were isolated from the leaves of a recently discovered, yet unidentified Congolese Ancistrocladus liana that shares some morphological characteristics with Ancistrocladus likoko. Two further new dimeric analogs, michellamines B₄ (3) and B₅ (4), were obtained, along with two previously likewise unknown monomers, ancistrobonsolines A₁ (5) and A₂ (6), which, besides one single known other example, are the only naphthyldihydroisoquinolines with an M-configured biaryl axis and R-configuration at C-3. Moreover, five com

SUBMITTER: Lombe BK 

PROVIDER: S-EPMC9078195 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature