Compliance With Standard Therapies and Remission Rates After Implementation of an Infantile Spasms Management Guideline.

ABSTRACT:

Background

We implemented an infantile spasms management guideline recommending standard therapies and, early start of next treatment. After six years, we determined (1) our compliance with standard therapies, (2) time to next treatment, and (3) rate of initial and three-month electroclinical remission with first, second, and third treatments.

Methods

This is a retrospective record review of newly diagnosed spasms from September 2012 to September 2018, with the onset age of two months to two years.

Results

Standard therapies (hormone or vigabatrin) were the first treatments in 114 of 115 consecutive patients. The second and third treatments were started within 14 days of failed treatment in only 21% and 24%, respectively. Remission with the first and second treatments

SUBMITTER: Mytinger JR 

PROVIDER: S-EPMC9078213 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature