A feasible strategy for self-assembly of gold nanoparticles via dithiol-PEG for photothermal therapy of cancers.

ABSTRACT: We designed and explored self-assembled gold nanoparticles (SAGNPs) by introducing dithiol modified polyethylene glycol (PEG) for internanoparticle cross-linking. SAGNPs could enhance uptake into cancer cells and be disintegrated by glutathione (GSH) to achieve tumor microenvironment-activated biodegradation. This assembled structure improved the photothermal effect compared to single gold nanospheres.

SUBMITTER: Fu Y 

PROVIDER: S-EPMC9078271 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature