JSFit: a method for the fitting and prediction of J- and S-shaped concentration-response curves.

ABSTRACT: Most monotonic S-shaped concentration-response curves (CRCs) can be satisfactorily described by a classical Hill equation. However, the Hill equation cannot effectively describe the non-monotonic J-shaped CRCs that display stimulation at low concentrations and inhibition at high concentrations. On the other hand, the physical meaning of the model parameters in current models describing the J-shaped CRCs is not very clear. It is well known that both toxicity experiments and the fitting process inevitably produce uncertainty. To effectively deal with the J-shaped concentration-response data with uncertainty and make the model parameters meaningful, we developed a method for the fitting of the J-shaped and/or S-shaped concentration-response data (simply called JSFit). The JSFit first uses one

SUBMITTER: Wang ZJ 

PROVIDER: S-EPMC9078288 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature