Adventures in radiosynthesis of clinical grade [⁶⁸Ga]Ga-DOTA-Siglec-9.

ABSTRACT: We finally managed to establish a protocol for generating Good Manufacturing Practice (GMP)-grade gallium-68-labelled 1,4,7,0-tetraazacyclododecane-1,4,7,10-tetraacetic acid conjugated sialic acid-binding immunoglobulin-like lectin 9 motif containing peptide ([⁶⁸Ga]Ga-DOTA-Siglec-9), the first radiopharmaceutical for positron emission tomography imaging of vascular adhesion protein 1.

SUBMITTER: Kakela M 

PROVIDER: S-EPMC9078465 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature